Senior Scientist, Mass Spectrometry

About the job

We are seeking a highly skilled and motivated Mass Spectrometry specialist to join our dynamic team. The primary focus of this role is to develop, validate, and apply advanced mass spectrometry-based methods for targeted lipidomic analysis. The ideal candidate will have deep experience in liquid chromatography-mass spectrometry (LC-MS) and a background/interest in lipid biochemistry. You will be responsible for supporting various preclinical projects. Importantly, you will be exposed to all aspects of preclinical drug discovery and knowledge and curiosity beyond bio-analytics is highly advantageous.

Responsibilities and abilities

• Operate and maintain a high-resolution mass spectrometer.

• Design, develop and optimize LC-MS/MS methods for the identification and quantification of a broad range of lipid classes.

• Implement and refine sample preparation protocols for diverse biological matrices (e.g., plasma, tissue, cells).

• Process raw LC-MS data using specialized software.

• Ensure the highest standards of data quality, reproducibility, and analytical rigor.

• Work closely with in vitro pharmacologists and medicinal chemists. Prepare clear and concise reports and present at project meetings.

Qualifications and experience

• Ph.D. in Analytical Chemistry, Biochemistry, or a related field with a focus on mass spectrometry.

• 3+ years post-PhD experience in a pharmaceutical, biotech or CRO environment.

• Candidates with a MSc are also welcome to apply, 5+ years of industry experience is a must for these applicants.

• Proven, extensive hands-on experience with the operation, maintenance, and troubleshooting of high-resolution mass spectrometers.

• Proficiency in sample preparation techniques for lipids (e.g., liquid-liquid extraction).

• Strong experience with data processing software for lipid identification and quantification.

• Demonstrated ability to develop and validate quantitative LC-MS/MS assays.

Personal qualities

• Highly driven, energetic, and self-motivated, with the ability to set and achieve your own goals.

• Broad scientific curiosity and flexibility to work on diverse topics.

• Thrives in a fast-paced, dynamic research environment.

• Enjoys collaborating with peers across disciplines, contributing creatively to projects, and rolling up their sleeves to help deliver results.

• Collaborative team player with strong interpersonal and communication skills.

• Excellent problem-solving skills and attention to detail.

• Excellent verbal and written communication skills in English.

We offer

• Employment for 32-40 hours/week.

• A stimulating environment with the opportunity to be part of an enthusiastic team with an entrepreneurial mindset.

• Support and attention for your personal and professional development.

• The chance to contribute directly to the development of novel therapeutic products for patients.

• A competitive remuneration package, including the opportunity to share in the company’s success.

About Scenic Biotech

Scenic Biotech is advancing modifier therapy, a radically new approach to treating genetic disorders. Instead of targeting the primary disease-causing mutation, modifier therapy seeks to rebalance health by acting on another function in the genome that can neutralize the disease impact, leading to a therapeutic effect. Our robust pipeline, derived from our proprietary Cell-Seq® platform, includes first-in-class small molecule programs that are wholly owned. By unlocking new pathways in the genome, Scenic will develop a range of modifier therapies to help patients.

We are passionate to make a difference and are recruiting highly motivated talents with various backgrounds to be part of our innovative journey towards the identification of drug targets and development of new therapies for patients suffering from diseases with an urgent medical need. Scenic Biotech is located in Amsterdam, one of the most vibrant European cities and is consistently ranked among the worlds’ cities with the highest quality of life.