About the job

As Senior DMPK Consultant you are a subject matter expert within Scenic Biotech. You will design and execute DMPK strategies from drug discovery to drug development and filing, to identify and address ADME/PK-centered matters for small molecule therapeutics.

By translating in vitro and nonclinical data you will support translational research and biomarker discovery and enable human PK, efficacious dose predictions and clinical risk assessment.

In this role, you will represent the DMPK function on projects, guiding and implementing strategies and enabling timely data-driven decision-making throughout the project life cycle. 

For this role we are looking for a consultant who's available 2-3 days per week. When you are interested in a part-time role and not a consultant, we can also hire you directly (Scenic Biotech contract).

Responsibilities and abilities

• Lead the in vitro and in vivo ADME, PK and toxicokinetic efforts within Scenic Biotech.

• Guide project teams to characterize, select, and advance small molecules with ADME properties that are fit to the therapeutic profile and support their advancement in clinical studies.

• Effectively communicate DMPK data and its interpretation for decision-making to project teams, and translate to predictions of human PK, PD, and safety, including the establishment of in vitro and/or in vivo correlations, PBPK and PK/PD models.

• Manage and oversee external CROs for completing in vitro and in vivo studies.

• Serve as a subject matter expert to contribute to (Non-)Clinical Pharmacokinetic and Pharmacology sections of regulatory (IND/CTA) filings, IB updates, and responses to regulatory queries.

Qualifications and experience

• You hold a PhD in pharmacology, or a relevant scientific discipline with at least 8 years of pharmaceutical or biotechnology industry experience in pharmacokinetics and pharmacology, including clinical trial and regulatory documentation.

• Demonstrated knowledge of ADME, PK/PD, and preclinical development of small molecules.

• Strong experience at pharmaceutical companies and/or CROs, regarding outsourcing of preclinical studies, vendor/client management.

• Working proficiency in English, written and oral.

Personal qualities

• Innovative thinking, solution-oriented, with enthusiasm, energy, and drive to operate in a fast-paced biotech environment.

• Excellent communication skills and ability to work in a rapidly evolving research and development organization.

• Strong critical thinking, planning and organizational skills.

We offer

• Challenging consultancy assignment for a period of minimal 12 months, two days per week, with the prospect of further extension and expansion. Hour rate in consultation.

• A stimulating environment with the opportunity to be part of an enthusiastic entrepreneurial team.

• The possibility to contribute to the development of novel therapeutic products for patients.

About Scenic Biotech

At Scenic Biotech, we are pioneering the field of genetic modifiers for rare genetic diseases. Using our revolutionary target discovery platform, we can systematically identify genes that suppress the detrimental consequences of a disease-causing process, unlocking new biology on a daily basis. With our diverse and international team (~55), we created a fast-paced, multi-disciplinary environment, where we work together to investigate these genes as potential drug targets and translate this into the development of innovative and new drugs.

We are passionate to make a difference and are currently recruiting highly motivated talents with various backgrounds to be part of our innovative journey towards the identification of drug targets and development of new therapies for patients suffering from diseases with an urgent medical need. Scenic Biotech is located in Amsterdam, one of the most vibrant European cities and is consistently ranked among the worlds’ cities with the highest quality of life.